BS-181

Nomen chemicum:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride

SMILES Code:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

InChi Code:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(). 19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15; 3,23H2,1-2H3,(H,24,27);

InChi Key:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Keyword:

Solubilitas: 

Repono: 

Descriptio:

BS-181 valde selectivum CDK inhibitor pro CDK7 cum IC(50) 21 nmol/L. Probatio aliarum CDKs ac aliorum 69 kinases ostendebant BS-181 solum CDK2 inhiberi in concentratione minore quam 1 micromol/L, cum CDK2 inhibitis 35-ovilibus minus potenter (IC(50) 880 nmol/L) quam CDK7. In cellulis MCF-7, BS-181 phosphorylationem CDK7 subiectarum inhibuit, cycli cycli promovendi comprehensionem et apoptosim ad inhibenda linearum cellularum cancri incrementum inhibuit et effectus in vivo antitumorem ostendit.

Target: CDK7