LDC000067

Nomen chemicum:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

SMILES Code:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)C2)=C1)(N)=O

InChi Code:

InChI=1S/C18H18N4O3S/c1-25-178-3-2-7-15(17)16-10-18(21-12-20-16)22-146-4-5-13( 9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H 20,21,22)

InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Keyword:

LDC000067; LDC-000067; LDC 000067

Solubilitas: 

Repono: 

Descriptio:

LDC000067 potens est CDK9 inhibitor et selectivus. LDC000067 in vitro transcriptionis inhibetur modo ATP-competitivo et dosis dependens. Gene expressio profiling cellularum cum LDC000067 tractatarum demonstravit selectivam reductionem brevium variantium, inter regulatores magni momenti proliferation et apoptosin. Analysis de novo RNA synthesis suggessit amplum munus positivum CDK9. In gradu hypothetico et celluloso, LDC000067 reproducti effectus propriae inhibitionis CDK9 quales sunt RNA polymerase II in genes intermissa, ac potissimum inductio apoptosis in cellulis cancri. LDC000067 nia P-TEFb-dependens in vitro transcriptio. Apoptosin inducit in vitro et in vivo in compositione cum BI 894999.

Target: CDK9