BLU-285
Product Detail
Product Tags
| Pack Size | Availability | Pretium (USD) |
| 1g | In Stock | 900 |
| 5g | In Stock | 3600 |
| 10g | In Stock | 6200 |
| Plus Sizes | Get Quotes | Get Quotes |
Nomen chemicum:
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4 ]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
SMILES Code:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C)(C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
InChi Code:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H; 7-10,28H2,1-2H3/t26-/m0/s1
InChi Key:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Keyword:
BLU-285, BLU 285, BLU285, Avapritinib
Solubilitas:Solutum in DMSO
Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).
Descriptio:
Avapritinib (BLU-285) demonstravit diam in vitro activitatem in KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Actio cellularis Avapritinib in KIT D816 mutants ab autophosphorylatione mali cellae leukemia cell linea HMC1.2 mensuratur, et P815 mus mastocytomi cellae lineae cum IC50=4 et 22 nM, respective. In Kasumi-1 cellulis, at(8, 21)-positiva AML cellula cum KIT exon 17 mutationis N822K, Avapritinib potenter KIT N822K mutant autophosphorylationem (IC50=40 nM), amni significantem, necnon cellularum multiplicationem (IC50= 75 nM) [1].
Target: KIT
