IPI-549

Nomen chemicum:

(S) -2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl )ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

SMILES Code:

O=C(C1=C2N=CC=CN2N=C1N)N[C@H](C3=CC4=C(C(N3C5=CC=CC=C5)=O)C(C#CC6=CN(C) N=C6)=CC=C4)C

InChi Code:

InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6- 8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3- 11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1

InChi Key:

XUMALORDVCFWKV-IBGZPJMESA-N

Keyword:

IPI-549, IPI 549, IPI549, 1693758-51-8 .

Solubilitas:Solutum in DMSO

Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

Descriptio:

IPI-549 vetat PI3Kγ cum IC50 ex 16 nM, cum >100-forma selectivity super alias lipidos et interdum cominas (PI3Kα IC50=3.2 μM, PI3Kβ IC50=3.5 μM, PI3Kδ IC50>8.4 μM). IPI549 aestimatur pro actione per omnem Classem I PI3K isoformes. Vinculum affinitatis IPI549 pro PI3K-γ determinatur metiendo singulas rates constantes et PI3K-α, β et δ utens aequilibrio fluorescenti titratione. IPI549 insigniter arcta ligans ad PI3Kγ invenitur cum Kd 290 pM et >58-duplici affinitate debiliores aliae formae isoformes I PI3K (PI3Kα Kd=17 nM, PI3Kβ Kd=82 nM, PI3Kδ Kd=23 M). In PI3K-α, -β, -γ, et -δ dependens phospho-AKT cellulosa pertentat, IPI549 demonstrat egregiam potentiam PI3K-γ (IC50=1.2 nM) et selectivam contra alias Classis I PI3K isoformes (>146-duplicas). Cellulares IC50s pro Classis I PI3Kα (250 nM), PI3Kβ (240 nM), PI3Kγ (1.2 nM), PI3Kδ (180 nM) determinantur in SKOV-3, 786-O, RAW 264.7, et RAJI cellulae, respective, vigilantia. inhibition of pAKT S473 by ELISA. Praeterea, IPI549 dosis dependenter PI3Kγ dependens vetat ossis medullis macrophagis (BMDM) migrationis dependens. IPI549 etiam contra tabellam 80 GPCRs, canales ion, et transportatores 10 μM inuenitur.

Target: PI3Kγ, PI3Kβ