Osimertinib Mesylate

Osimertinib Mesylate
  • Nomen:AZD-9291 (Mesylate); Tagrisso; Osimertinib Mesylate
  • Catalogue No.CPDB0137
  • CAS No.:1421373-66-1
  • Pondus hypotheticum:595.72
  • Formulae chemica:C29H37N7O5S
  • Investigationes scientificae tantum, non aegros.

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    1g In Stock 180
    5g In Stock 600
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    Nomen chemicum:

    N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl) pyrimidin-2-yl) amino )Phenyl) acrylamide mesylate

    SMILES Code:

    CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

    InChi Code:

    InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28 )20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2 -6H3,(H,30,36)(H,29,31,32);

    InChi Key:

    FUKSNUHSJBTCFJ-UHFFFAOYSA-N

    Keyword:

    AZD-9291, AZD9291, AZD 9291, Tagrisso, Osimertinib Mesylate, 1421373-66-1

    Solubilitas:Solutum in DMSO

    Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

    Descriptio:

    Osimertinib, quae mereletinib et AZD-9291 cognominata est, tertia generatio EGFR inhibitor est, promissionem in studiis preclinicis ostendit et spem praebet aegris cum carcinomata pulmonis provecta quae resistentia existentibus EGFR inhibitoribus facti sunt. AZD9291 multum activum est in exemplaribus preclinicis et in exemplaribus animalis bene toleratur. EGFR mutationum et activum et renitentem inhibet dum EGFR formae normali parcens, quae in normalibus cellulis et cutibus inest, minuendo latus effectus cum medicamentis nunc in promptu offendit. Osimertinib probatus est die Nov. MMXV.

    Target: EGFR


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