BLU-9931
Product Detail
Product Tags
| Pack Size | Availability | Pretium (USD) |
| 100mg | In Stock | 220 |
| 300mg | In Stock | 500 |
| 1g | In Stock | 1350 |
| Plus Sizes | Get Quotes | Get Quotes |
Nomen chemicum:
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
SMILES Code:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
InChi Code:
InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33; )(H,29,31,32)
InChi Key:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Keyword:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Solubilitas:Solutum in DMSO
Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).
Descriptio:
In cellulis MDA-MB-453, BLU9931 potenter vetat phosphorylationem FGFR4 iter significans. BLU9931 inhibet multiplicationem linearum cellularum HCC quae FGFR4 integram significantem complexum exprimunt, ut Hep 3B, HUH-7, et JHH-7 cellularum linearum, cum EC50 of.<1 μM. BLU9931 etiam multiplicationem in PDX derivatis lineis cellularum inhibet cum FGFR4 integra via signans[1]. BLU9931 tumorem DECREMENTUM in carcinomate hepatocellulares inducit exempla quae complexum ligandi/receptoris muneris FGF19/FGFR4/KLB constans exprimunt et addit ad indicem crescentem agentium anti-FGFR4[2].
Target: FGFR4
