Bardoxolone yl

Bardoxolone yl
  • Nomen:RTA-402; NSC-713200; TP-155C; Methyl-CDDO; Methyl CDDO; Bardoxolone yl
  • Catalogue No.CPDD0995
  • CAS No.:218600-53-4
  • Pondus hypotheticum:505.69
  • Formulae chemica:C32H43NO4
  • Investigationes scientificae tantum, non aegros.

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    Nomen chemicum:

    (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a; 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylata.

    SMILES Code:

    O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

    InChi Code:

    InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5) 16-19 (18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

    InChi Key:

    WPTTVJLTNAWYAO-OROHISIGSA-N

    Keyword:

    Bardoxolone yl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

    Solubilitas:Solutum in DMSO

    Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

    Descriptio:

    Synthetica oleanana triterpenoidis CDDO (Item No. 81035) est activator Nrf2, quae multiplicationem vetat et differentiam et apoptosim inducit in cellulis cancri variis. C-28 methyl oster CDDO (CDDO methyl ester) impedit synthesim cellularum oxydi nitrici inducibilis synthaseos (iNOS) et inducibilis COX-2 in INF-γ-activi macrophages muris cum IC50 valore 0.11 nM. Apoptosin inducit, differentiam inducit, et responsionem inflammationem inducit in variis cellulis tumore per inhibitionem significationis IκBα kinasi/NF-κB. CDDO methyl ester potentem habet antidiabeticam actionem, proinflammationem cytokinam reducens expressionem in altam victu pinguedinem generis 2 diabetici mures et in Leprdb/db mures et AMP-activus interdum kinasus et activation in musculo et hepate LKB1 excitato

    Target: NF-kB


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