GSK2256098

Nomen chemicum:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridinum-4-yl)amino)-N-methoxybenzamide

SMILES Code:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

InChi Code:

InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-168- 6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3(H2,22,28)(H2,22,23,24)

InChi Key:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Keyword:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Solubilitas:Solutum in DMSO

Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

Descriptio:

GSK2256098, quae GTPL7939 cognominatur, est adhaesio focalis kinasi-1 (FAK) inhibitoris cum actionibus potentialibus antiangiogenicis et antineoplasticis. FAK inhibitor GSK2256098 vetat FAK, quae impedire potest activationem integram mediatam plurium amni notarum transductionis meatus, incluso ERK, JNK/MAPK et PI3K/Akt, inhibens tumorem cellam migrationem, multiplicationem et salutem et tumorem angiogenesis. kinase tyrosinum FAK normaliter ligando ad integritatem in matrice extracellulare (ECM) excitari potest, sed in variis tumoribus cellularum specierum tumore constituto agi potest.

Target: FAK