Batefenterol

Nomen chemicum:

(R) -1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)amino) methyl) -5-methoxyphenyl)amino) -3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"

SMILES Code:

O=C(OC1CCN(CCC(NC2=CC(OC))=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

InChi Code:

InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(1 6-19-46)53-40(51)44-32-10-6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22; 27,35,42,47-48H,15-20,23-24H2,1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

InChi Key:

URWYQGVSPQJGGB-DHUJRADRSA-N

Keyword:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6.

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

Batefenterolus muscarinicus est antagonista et aba2-adrenergicus receptor (β2-AR) agonista (Kis = 1.4, 1.3, et 3.7 nM, pro hM2, hM3, et hβ2-AR, respective in primordium ligandi radioligandi). Batefenterolus ostendit potentem hβ2-AR agonistam activitatem (EC50 = 0.29 nM) cum 440- et 320-plicare selectivam functionem super hβ1- et hβ3-ARs, respectively.1 Batefenterolus relaxationem musculi lenis inducit (EC50 = 11 nM) in arteriae arteriae solitariae Guineae sus. bronchoconstrictor responsionis bronchoprotection in Guinea sus bronchoprotection intenta (ED50 = 6.4 μg/mL). Formulae batefenterol continentes in iudiciis clinicis sunt ut morbos pulmonis obstructivos longos (COPD).

Target: β2-adrenoceptor