THZ531

Aha kemịkalụ:

(R,E)-N-(4- (3-((5-chloro-4-- (1H-indol-3-yl))pyrimidin-2-yl)amino)piperidine-1-carbonyl) phenyl)-4- (dimethylamino) ma-2-enamide

Koodu Ọchịchọ:

"O=C(NC1=CC=C(C(N2C[C@H])(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCCC2=O)C= C1)/C=C/CN(C)C"

Koodu InChi:

InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22 (19-38) 35-30-33-18-25 (31)28 (36-30) 24-17-32-26-9-4-3-8-23 (24)26/h3-4, 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/ t22-/m1/s1

Igodo InChi:

RUBYHLPRZRMTJO-MOVYNIQHSA-N

Okwu:

THZ-531, THZ 531, THZ531, 1702809-17-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

THZ531 bụ ihe mgbochi CDK12 na CDK13 covalent inhibitor. Kinases nke dabere na cyclin 12 na 13 (CDK12 na CDK13) na-arụ ọrụ dị oke egwu na nhazi nke ederede mkpụrụ ndụ ihe nketa. THZ531 na-atụgharị anya na cysteine ​​dị na mpụga ngalaba kinase. THZ531 na-ebute mfu nke mkpụrụ ndụ ihe nketa na mfu nke elongating na hyperphosphorylated RNA polymerase II. THZ531 na-ebelata nke ukwuu okwu nke mkpụrụ ndụ ihe nketa mmeghachi omume DNA na mkpụrụ ndụ ihe na-akpata ihe ntụgharị ihe metụtara nnukwu nkwalite. THZ531 butere ọnwụ mkpụrụ ndụ apoptotic n'ụzọ dị egwu. Obere ụmụ irighiri ihe nwere ike ịchụ CDK12 na CDK13 nwere ike si otú a nyere aka chọpụta ụdị ọrịa kansa nke dabere na ọrụ kinase ha.

Ebumnuche: CDK