MC180295

Aha kemịkalụ:

Rel- (4-amino-2-(((2S)-bicyclo[2.2.1] heptan-2-yl) amino) thiazol-5-yl) (2-nitrophenyl) methanone

Koodu Ọchịchọ:

O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

Koodu InChi:

InChi=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16) )19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10? ,12-/m0/s1

Igodo InChi:

JRNXAQINDCOHGS-CBINBANVSA-N

Okwu:

Solubility: 

Nchekwa: 

Nkọwa:

MC180295 bụ onye na-egbochi CDK9 nke ukwuu (IC50 = 5 nM). (MC180295 nwere ọrụ mgbochi ọrịa cancer sara mbara na vitro ma dị irè na ụdị ọrịa cancer vivo. Ọzọkwa, mgbochi CDK9 na-eme ka ihe mgbochi mgbochi mgbochi α-PD-1 na vivo, na-eme ka ọ bụrụ ebumnuche magburu onwe ya maka ọgwụgwọ epigenetic nke ọrịa cancer.

Aha njirimara: CDK9