Voruciclib

Aha kemịkalụ:

2- (2-Chloro-4- (trifluoromethyl) phenyl) -5,7-dihydroxy-8- ((2R,3S) -2- (hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-1-benzopyran -4-otu

Koodu Ọchịchọ:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Koodu InChi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(32-21) 19)20)11-3-2-10 (6-13 (11)23)22 (24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

Igodo InChi:

MPGRAKIAJJGMM-OCCSQVGLSA-N

Okwu:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Solubility: 

Nchekwa: 

Nkọwa:

Voruciclib, makwaara dị ka P1446A-05, bụ protein kinase inhibitor kpọmkwem maka cyclin-based kinase 4 (CDK4) nwere ọrụ antineoplastic. CDK4 inhibitor P1446A-05 na-egbochi mgbanwe oge nke CDK4-mediated G1-S, na-ejide ịnya igwe na igbochi uto mkpụrụ ndụ kansa. A na-achọta serine / threonine kinase CDK4 na mgbagwoju anya na ụdị D-ụdị G1 cyclins na ọ bụ kinase mbụ na-arụ ọrụ n'elu mkpali mitogenic, na-ahapụ mkpụrụ ndụ site na ọkwa nke quiescent n'ime G1 / S ịgba ígwè ịgba ígwè; E gosiputara ogige CDK-cyclin ka ọ na-eme ka phosphorylate ihe ntụgharị ederede retinoblastoma (Rb) n'oge G1, na-ewepụ histone deacetylase (HDAC) na igbochi mmegide transcriptional.

Aha njirimara: CDK4