THZ2

Aha kemịkalụ:

N-[3-[[5-chloro-4- (1H-indol-3-yl) pyrimidin-2-yl] amino] phenyl] -3-[[(E) -4- (dimethylamino) ma-2- enoyl]amino]benzamide

Koodu Ọchịchọ:

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5

Koodu InChi:

InChi=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23 (17-22)37-31-34-19-26 (32)29 (38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H, 35,40)(H,36,41)(H,34,37,38)/b14-7+

Igodo InChi:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Okwu:

THZ-2, THZ 2, THZ2, 1604810-84-5

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

THZ2, ihe analog nke THZ1, nke nwere ike ịgwọ ọrịa cancer ara na-adịghị mma (TNBC), ọ bụ ihe mgbochi CDK7 dị ike ma họrọ nke na-emeri nkwụsị nke THZ1 na vivo. IC50: CDK7= 13.9 nM; Mkpụrụ ndụ TNBC = 10 nM

Ebumnuche: CDK