Alvocidib

Aha kemịkalụ:

2- (2-chlorophenyl) -5,7-dihydroxy-8- ((3R,4S) -3-hydroxy-1-methylpiperidin-4-yl) -4H-chromen-4-otu

Koodu Ọchịchọ:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Koodu InChi:

InChi=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21 (19) 20) 11-4-2-3-5-13 (11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- ,17+/m1/s1

Igodo InChi:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Okwu:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Solubility: 

Nchekwa: 

Nkọwa:

Alvocidib bụ ngwakọta N-methylpiperidinyl chlorophenyl flavone sịntetik. Dị ka onye na-egbochi cyclin-based kinase, alvocidib na-eme ka njide sel cell site na igbochi phosphorylation nke cyclin-dependent kinases (CDKs) na site na-achịkwa cyclin D1 na D3 okwu, na-akpata G1 cell cycle arrest na apoptosis. Onye nnọchi anya a bụkwa onye na-egbochi ọrụ adenosine triphosphate. Lelee maka nnwale ụlọ ọgwụ na-arụsi ọrụ ike ma ọ bụ nnwale ụlọ ọgwụ mechiri emechi site na iji nnọchite a.

Ebumnuche: CDK