BS-181

Aha kemịkalụ:

N5- (6-aminohexyl) -N7-benzyl-3-isopropylpyrazolo [1,5-a] pyrimidine-5,7-diamine hydrochloride.

Koodu Ọchịchọ:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Koodu InChi:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(27-22) 19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15 ,23H2,1-2H3,(H,24,27);1H

Igodo InChi:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Okwu:

Solubility: 

Nchekwa: 

Nkọwa:

BS-181 bụ onye na-egbochi CDK nke ukwuu maka CDK7 nwere IC(50) nke 21 nmol/L. Nnwale nke CDK ndị ọzọ yana kinase 69 ọzọ gosiri na BS-181 na-egbochi CDK2 na mkpokọta dị ala karịa 1 micromol/L, na CDK2 na-egbochi 35-fold obere ike (IC(50) 880 nmol/L) karịa CDK7. N'ime mkpụrụ ndụ MCF-7, BS-181 gbochiri phosphorylation nke CDK7 substrates, na-akwalite njide okirikiri cell na apoptosis iji gbochie uto nke ahịrị mkpụrụ ndụ kansa, ma gosipụta mmetụta antitumor na vivo.

Aha njirimara: CDK7