LDC000067

Aha kemịkalụ:

3-[6- (2-Methoxyphenyl) -4-pyrimidinyl] amino] benzenemethanesulfonamide.

Koodu Ọchịchọ:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2=C1)(N)=O

Koodu InChi:

InChi=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13( 9-14)11-26 (19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

Igodo InChi:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Okwu:

LDC000067; LDC-000067; LDC 000067

Solubility: 

Nchekwa: 

Nkọwa:

LDC000067 bụ ihe mgbochi CDK9 nwere ike na nhọrọ. LDC000067 amachibidoro ndegharị in vitro n'ụdị asọmpi ATP na dabere dose. Nkọwapụta mkpụrụ ndụ mkpụrụ ndụ nke e ji LDC000067 emeso ya gosipụtara mbelata nhọrọ nke mRNA dị mkpụmkpụ, gụnyere ndị na-achịkwa mkpa nke mgbasa na apoptosis. Nyocha nke njikọ de novo RNA na-atụ aro ọrụ dị oke mma nke CDK9. N'ọkwa molekụla na cellular, LDC000067 weputara mmetụta njirimara nke mgbochi CDK9 dị ka nkwụsịtụ RNA polymerase II na mkpụrụ ndụ ihe nketa na, nke kachasị mkpa, ntinye apoptosis na mkpụrụ ndụ kansa. LDC000067 na-egbochi ndenye P-TEFb dabere na in vitro. Na-ebute apoptosis in vitro na in vivo yana BI 894999.

Aha njirimara: CDK9