MSC2530818

Aha kemịkalụ:

[(2S) -2- (4-Chlorophenyl) pyrrolidin-1-yl] (3-methyl-1H-pyrazolo [3,4-b] pyridin-5-yl) methanone

Koodu Ọchịchọ:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

Koodu InChi:

InChi=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1

Igodo InChi:

ODRITQGYYWHQGM-INIZCTEOSA-N

Okwu:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

MSC2530818 bụ onye nwere ike, Nhọrọ, na Oral Bioavailable CDK8 Inhibitor nwere CDK8 IC50 = 2.6 nM; PK amụma mmadụ: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F> 75% MSC2530818 na-egosiputa ezigbo kinase selectivity, biochemical na cellular ike, microsomal nkwụsi ike, na ọnụ na-adị ndụ. MSC2530818 na-egosipụta ike kwesịrị ekwesị na nhọrọ iji nwee ọganihu n'ime preclinical na vivo arụmọrụ na ọmụmụ nchekwa.

Ebumnuche: CDK