PQR530

Aha kemịkalụ:

(S) -4- (difluoromethyl) -5- (4- (3-methylmorpholino) -6-morpholino-1,3,5-triazin-2-yl) pyridin-2-amine

Koodu Ọchịchọ:

NC1=NC=C(C2=NC(N3[C@@H](C)COCC3=NC(N4CCOCC4)=N2)C(C(F)F)=C1

Koodu InChi:

InChi=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(1) 9)20)23-17 (25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/ t11-/m0/s1

Igodo InChi:

SYKBZXMKAPICSO-NSHDSACASA-N

Okwu:

PQR530, PQR-530, PQR 530, 1927857-61-1

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

PQR530 bụ ihe mgbochi pan-PI3K/mTORC1/2 nwere ike dị ukwuu. PQR530 gbochiri protein kinase B (PKB, pSer473) na protein ribosomal S6 (pS6, pSer235/236) phosphorylation na ụkpụrụ IC50 nke 0.07 µM. PQR530 gosipụtara ọmarịcha nhọrọ n'elu nnukwu panel nke kinase, yana nhọrọ nhọrọ dị mma yana enzymes nnabata na-enweghị njikọ na ọwa ion. Ọzọkwa, PQR530 gosipụtara ike na panel nke ahịrị mkpụrụ ndụ kansa 44 (NTRC OncolinesTM) iji gbochie uto mkpụrụ ndụ kansa (pụtara uru maka GI50 nke 426 nM). Ngwa ọnụ nke PQR530 maka ụmụ oke rụpụtara PK nha nha nha ma gosipụta ezigbo bioavailability ọnụ yana ezigbo ntinye ụbụrụ.

Ebumnuche: PI3K/mTOR