Bardoxolone methyl

Bardoxolone methyl
  • Aha:RTA-402; NSC-713200; TP-155C; Methyl-CDDO; Methyl CDDO; Bardoxolone methyl
  • Nọmba katalọgụ:CPDD0995
  • Nọmba CAS:218600-53-4
  • Arọ Molecular:505.69
  • Usoro kemịkalụ:C32H43NO4
  • Maka nyocha sayensị naanị, ọ bụghị maka ndị ọrịa.

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    Aha kemịkalụ:

    (4aS,6aR,6bS,8aR,12aS,14aR,14bS) -methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a; 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

    Koodu Ọchịchọ:

    O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

    Koodu InChi:

    InChi=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29 (5) 16-19 (18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

    Igodo InChi:

    WPTTVJLTNAWYAO-OROHISIGSA-N

    Okwu:

    Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, methyl CDDO, CDDO methyl ester, 218600-53-4

    Solubility:Soluble na DMSO

    Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

    Nkọwa:

    Oleanane triterpenoid CDDO synthetic (Ngwa nke No. 81035) bụ Nrf2 activator nke na-egbochi mgbasawanye ma na-ebute ọdịiche na apoptosis na mkpụrụ ndụ cancer dị iche iche. C-28 methyl ester nke CDDO (CDDO methyl ester) na-egbochi njikọ cellular nke inducible nitric oxide synthase (iNOS) na COX-2 inducible na INF-γ-activated mouse macrophages na IC50 uru nke 0.11 nM. Ọ na-ebute apoptosis, na-ebute ọdịiche, ma na-egbochi nzaghachi mkpali na mkpụrụ ndụ tumor dị iche iche site na mgbochi nke IκBα kinase / NF-κB. CDDO methyl ester nwere ọrụ antidiabetic siri ike, na-ebelata okwu cytokine proinflammatory na ụdị oke abụba 2 na-eri nri dị elu yana na ụmụ oke Leprdb / db na ịkpalite protein kinase na-arụ ọrụ AMP na nkwalite LKB1 na akwara na imeju.

    Ebumnuche: NF-kB


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