Osimertinib Mesylate

Aha kemịkalụ:

N- (2- (2- (dimethylamino) ethyl) (methyl) amino) -4-methoxy-5- ((4- (1-methyl-1H-indol-3-yl) pyrimidin-2-yl) amino. phenyl) acrylamide mesylate

Koodu Ọchịchọ:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

Koodu InChi:

InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21 (31-28 )20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2 -6H3, (H,30,36)(H,29,31,32);1H3, (H,2,3,4)

Igodo InChi:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Okwu:

AZD-9291, AZD9291, AZD 9291, Tagrisso,Osimertinib Mesylate, 1421373-66-1

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

Osimertinib, nke a makwaara dị ka mereletinib na AZD-9291, bụ onye na-emechi EGFR ọgbọ nke atọ, gosipụtara nkwa na ọmụmụ ihe ọmụmụ ma na-enye olileanya maka ndị ọrịa nwere ọrịa cancer akpa ume dị elu bụ ndị na-eguzogide ndị na-emechi EGFR dị adị. AZD9291 na-arụsi ọrụ ike na ụdị preclinical ma na-anabata ya nke ọma na ụdị anụmanụ. Ọ na-egbochi ma mmụgharị EGFR na-arụ ọrụ na nke na-eguzogide ma na-echekwa ụdị EGFR nkịtị nke dị na anụ ahụ nkịtị na sel eriri afọ, si otú a na-ebelata mmetụta ndị a na-enweta na ọgwụ ndị dị ugbu a. A kwadoro Osimertinib na Nov. 2015.

Ebumnuche: EGFR