LX-2761

Aha kemịkalụ:

N- (1- ((2- (Dimethylamino) ethyl) amino) -2-methyl-1-oxopropan-2-yl) -4- (2-methyl-5-(2S,3R,4R, 5S,6R) -3,4,5-trihydroxy-6- (methylthio) tetrahydro-2H-pyran-2-yl) benzyl) phenyl) -butanamide.

Koodu Ọchịchọ:

O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3=CC=C2C)C=C1

Koodu InChi:

InChi=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21 (12-14-22)8-7-9-25 (36)34-32 (2,3)31 (40)33-16-17-35(4)5/h10-15, 19,26-30,37-39H,7-9,16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30 -/m1/s1

Igodo InChi:

BNPZTRDIESRGTC-IXYVTWBDSA-N

Okwu:

LX-2761, LX2761, LX 2761, 1610954-97-6

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

LX2761 bụ ihe mgbochi SGLT1 na-eme mpaghara nke nwere ike dị ukwuu na vitro ma na-egbu oge nnabata glucose eriri afọ na vivo iji melite njikwa glycemic. LX2761 nwere hSGLt1 2.2 nM; hSGLT2 2.7 nM na F% =<2. LX2761 bụ ihe dị ike nke ukwuu, kwụsiri ike na kemịkalụ, yana molecule amachibidoro ọkụ nke nwetara akaebe nke echiche na OGTT na obere doses. Emebere LX2761 ka ọ nọrọ n'ime eriri afọ mgbe nnyefe ọnụ gasịrị iji gbochie SGLT1 na mpaghara na-enweghị emetụta usoro SGLT1/2 na akụrụ.

Ebumnuche: SGLT1