Nazartinib; EGF816; NVS-816

Nazartinib; EGF816; NVS-816
  • Aha:Nazartinib; EGF816; NVS-816
  • Nọmba katalọgụ:CPDB3615
  • Nọmba CAS:"1508250-71-2"
  • Arọ Molecular:495.02
  • Usoro kemịkalụ:C26H31ClN6O2
  • Maka nyocha sayensị naanị, ọ bụghị maka ndị ọrịa.

    Nkọwa ngwaahịa

    Mkpado ngwaahịa

    Nha ngwugwu Nnweta Ọnụ ego (USD)
    25mg Dị na ngwaahịa 290
    50mg Dị na ngwaahịa 450
    100mg Dị na ngwaahịa 630
    1g Dị na ngwaahịa 1600
    Nha ndị ọzọ Nweta Quotes Nweta Quotes

    Aha kemịkalụ:

    (R, E) -N- (7-chloro-1- (1- (4- (dimethylamino)ma-2-enoyl)azepan-3-yl) -1H-benzo [d] imidazole-2-yl) 2-methylisonicotinamide

    Koodu Ọchịchọ:

    O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4

    Koodu InChi:

    InChi=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15 -32 (17-20) 23 (34) 11-7-14-31 (2) 3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3 , (H,29,30,35)/b11-7+/t20-/m1/s1

    Igodo InChi:

    IOMMMLWIABWRKL-WUTDNEBXSA-N

    Okwu:

    Nazartinib, EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

    Solubility:Soluble na DMSO

    Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

    Nkọwa:

    Nazartinib, nke a makwaara dị ka EGF816 na NVS-816, bụ ọnụ ọnụ dịnụ, enweghị ike ịgbanwe, ọgbọ nke atọ, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, nwere ọrụ antineoplastic. EGF816 na-ejikọta ọnụ ma gbochie ọrụ nke ụdị mutant nke EGFR, gụnyere mutant T790M EGFR, si otú a na-egbochi mgbasa ozi EGFR na-agbasa. Nke a nwere ike ịkpata ọnwụ cell ma gbochie uto tumor na EGFR-overexpressing tumor cell. EGF816 na-akacha mma na-egbochi ụdị EGFR gbanwetụrụ gụnyere T790M, ngbanwe nke abụọ enwetara, ma nwee ike nweta uru ọgwụgwọ na etuto ahụ nwere nguzogide mgbasa ozi T790M ma e jiri ya tụnyere ndị ọzọ EGFR tyrosine kinase inhibitors.

    Ebumnuche: EGFR


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