Batefeenterol

Aha kemịkalụ:

"(R) -1- (3-(2-chloro-4-((2-hydroxy-2-- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl)amino) methyl -5-methoxyphenyl) amino -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl] -2-ylcarbamate Batefenterol Succinate"

Koodu Ọchịchọ:

O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

Koodu InChi:

InChi=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30(47)39-30(47) 29)12-14-37 (49)45-39)43-38 (50)17-20-46-18-15-27 (16-19-46)53-40 (51)44-32-10- 6-5-9-28 (32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

Igodo InChi:

URWYQGVSPQJGGB-DHUJRADRSA-N

Okwu:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

Batefenterol bụ onye na-emegide muscarinic na β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, na 3.7 nM, maka hM2, hM3, na hβ2-AR, n'otu n'otu na nyocha nke njide redioligand). Batefenterol na-egosipụta ọrụ agonist hβ2-AR dị ike (EC50 = 0.29 nM) na 440- na 320-fold functionivity selectivity n'elu hβ1- na hβ3-ARs, n'otu n'otu. anụ ahụ ma na-egbochi nzaghachi bronchoconstrictor na nyocha nke bronchoprotection pig (ED50 = 6.4 µg/mL). Usoro ndị nwere batefenterol nọ na ule ụlọ ọgwụ iji gwọọ ọrịa na-adịghị ala ala (COPD).

Ebumnuche: β2-adrenoceptor