BLU-667

BLU-667
  • Non:BLU-667
  • Nimewo katalòg:CPD2049
  • Nimewo CAS:2097132-94-8
  • Pwa molekilè:532.27
  • Fòmil chimik:C28H33FN8O2
  • Pou rechèch syantifik sèlman, pa pou pasyan yo.

    Pwodwi detay

    Tags pwodwi

    Gwosè pake Disponibilite Pri (USD)

    Non Chimik:

    (1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pirazol-1-yl)fenil)etil)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pirazol-3-yl)amino)pirimidin-2-yl)cyclohexane-1-carboxamide

    Kòd SMILES:

    CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

    Kòd InChi:

    InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

    InChi kle:

    HUQPYQIGHTXBNW-BDHWGLMFSA-N

    Mot:

    BLU-667; BLU 667; BLU667

    Solibilite:DMSO

    Depo: 

    Deskripsyon:

    BLU-667 se yon inibitè ki pisan ak selektif nan mitasyon RET, fizyon, ak prevwa mutan rezistan. Fizyon RET yo se faktè kle nan plizyè kansè, ki gen ladan kansè nan poumon ak tiwoyid, ak rechèch nou an sijere ke RET jwe tou yon wòl kle nan kèk kansè nan kolon ak tete. Lè yo vize an menm tan prensipal chofè a ak prevwa mutan rezistan ki rann selil kansè yo ensansib nan tretman ak dwòg kounye a apwouve,

    Sib: RET


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