MSC2530818

Non Chimik:

[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

Kòd SMILES:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

Kòd InChi:

InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4- 6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1

InChi kle:

ODRITQGYYWHQGM-INIZCTEOSA-N

Mot:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).

Deskripsyon:

MSC2530818 se yon Inibitè CDK8 ki pisan, selektif, ak oral byodisponib ak CDK8 IC50 = 2.6 nM; Prediksyon PK imen: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 montre ekselan selektivite kinaz, puisans byochimik ak selilè, estabilite mikwosomal, epi li se biodisponib oral. MSC2530818 demontre pisans apwopriye ak selektivite pou pwogrese nan etid preklinik sou efikasite ak sekirite nan vivo.

Sib: CDK