GSK2256098

Non Chimik:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pirazol-5-yl)amino)piridin-4-yl)amino)-N-methoxybenzamid

Kòd SMILES:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Kòd InChi:

InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22 -18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23 ,24)

InChi kle:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Mot:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).

Deskripsyon:

GSK2256098, ke yo rele tou GTPL7939, se yon inibitè fokal adhesion kinase-1 (FAK) ak aktivite potansyèl antiangiogenic ak antineoplastic. FAK inhibitor GSK2256098 inibit FAK, ki ka anpeche deklanchman entegrin-medyatè plizyè chemen transduction siyal en, ki gen ladan ERK, JNK/MAPK ak PI3K/Akt, kidonk anpeche migrasyon selil timè, pwopagasyon ak siviv, ak anjojenèz timè. Tyrosine kinase FAK nòmalman aktive pa lye ak entegrin nan matris ekstraselilè (ECM) men yo ka regilasyon ak konstititif aktive nan divès kalite selil timè.

Sib: FAK