THZ531

Inoa Kimia:

(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) aka-2-enamide

SMILES Code:

"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "

Code InChi:

InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4, 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/ t22-/m1/s1

Ki InChi:

RUBYHLPRZRMTJO-MOVYNIQHSA-N

Hua'ōlelo:

THZ-531, THZ 531, THZ531, 1702809-17-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO THZ531 kahi mea hoʻopaneʻe CDK12 a me CDK13 covalent inhibitor. ʻO Cyclin-dependent kinases 12 a me 13 (CDK12 a me CDK13) ke kuleana koʻikoʻi i ka hoʻoponopono ʻana i ka transcription gene. Hoʻopio ʻo THZ531 i kahi cysteine ​​ma waho o ka domain kinase. ʻO THZ531 ke kumu o ka nalo ʻana o ka hōʻike gene me ka nalo like ʻole o ka elongating a me ka hyperphosphorylated RNA polymerase II. Hoʻemi nui ʻo THZ531 i ka hōʻike ʻana i nā genes pane pōʻino DNA a me nā ʻano genes transcription factor super-enhancer. ʻO THZ531 i hoʻokomo nui i ka make apoptotic cell. Hiki i nā molekole liʻiliʻi ke kuhikuhi pono i ka CDK12 a me CDK13 hiki ke kōkua i ka ʻike ʻana i nā subtypes maʻi maʻi i hilinaʻi nui ʻia i kā lākou hana kinase.

Kuhikuhi: CDK