MEK

CAT #	Inoa Huahana	wehewehe
CPDB0157	BI-847325	ʻO BI-847325 he mea koho pālua MEK / Aurora kinase inhibitor me IC50 waiwai o 3, 25, 15, 25, a me 4 nM no X. laevis Aurora B, kanaka Aurora A a me Aurora C, a me kanaka MEK1 a me MEK2. Hiki iā ia ke keʻakeʻa i ka ulu a me ke ola ʻana o nā laina melanoma cell treatment-naive a me ka lāʻau lapaʻau, e hoʻemi ana i ka hōʻike ʻana o MEK a me Mcl-1 me ka hoʻonui ʻana i ka hōʻike o ka Bim protein pro-apoptotic. Ma ka 70 mg/kg, hoʻoulu ʻo BI-847325 i ka apoptosis i ka lāʻau lapaʻau-naive a me ka lāʻau lapaʻau xenografted melanoma i vivo.