in vitro Pharmacokinetic Assays

Hoʻokumu kā mākou hui pharmacokinetic i ka hoʻomohala preclinical, ka nānā ʻana i ka DMPK a me ka hoʻopaʻa inoa IND. Ua hoʻokumu mākou i kahi kahua ʻenehana screening in vitro & in vivo i kākoʻo i ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau. Hāʻawi ʻo Caerulum Pharma i ka lawelawe maʻalahi a pilikino no nā hoʻonā DMPK kūpono a me ke kumu kūʻai e neʻe i kāu noiʻi i mua.

1. Haʻawina haʻawina

Nā mole liʻiliʻi, nā huahana kūlohelohe, polypeptides.

2. Loaʻa nā lawelawe

ʻO ka hoʻopaʻa ʻana i ka protein plasma/tissue

Plasma i ke koko ratio

ʻO ke kūpaʻa microsomal metabolic o ka ate

Paʻa i ka kaʻa a me ka plasma

ʻIkepili metabolite

CYP reaction phenotyping

Kāohi CYP

3.Ma ke kukulu ana

Hepatocyte Induction

Caco-2 Permeability

UGT pane phenotyping


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