Hoʻokumu kā mākou hui pharmacokinetic i ka hoʻomohala preclinical, ka nānā ʻana i ka DMPK a me ka hoʻopaʻa inoa IND. Ua hoʻokumu mākou i kahi kahua ʻenehana screening in vitro & in vivo i kākoʻo i ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau. Hāʻawi ʻo Caerulum Pharma i ka lawelawe maʻalahi a pilikino no nā hoʻonā DMPK kūpono a me ke kumu kūʻai e neʻe i kāu noiʻi i mua.
1. Haʻawina haʻawina
Nā mole liʻiliʻi, nā huahana kūlohelohe, polypeptides.
2. Loaʻa nā lawelawe
ʻO ka hoʻopaʻa ʻana i ka protein plasma/tissue
Plasma i ke koko ratio
ʻO ke kūpaʻa microsomal metabolic o ka ate
Paʻa i ka kaʻa a me ka plasma
ʻIkepili metabolite
CYP reaction phenotyping
Kāohi CYP
3.Ma ke kukulu ana
Hepatocyte Induction
Caco-2 Permeability
UGT pane phenotyping