| CAT # | Inoa Huahana | wehewehe |
| CPD9470 | Obeticholic-Acid | ʻO ka Obeticholic Acid (INT747; 6-ECDCA) he huaʻōlelo hou ia o ka cholic acid e hana ana ma ke ʻano he agonist FXR ikaika a koho e hōʻike ana i ka hana anticholeretic i loko o ka vivo rat model of cholestasis. Hoʻopaʻa ia i ka ʻāʻī ʻana o ka ʻiʻo a me ka neʻe ʻana a me ka paipai ʻana i ka ʻokoʻa adipocyte a hoʻoponopono i ka hana adipose cell in vivo. |
| CPD100579 | fexaramine | ʻO Fexaramine kahi agonist o ka farnesoid X receptor (FXR), ʻo ia ka bile acid-activated nuclear receptor e hoʻomalu i ka bile-acid synthesis, conjugation a me ka lawe ʻana, a me ka lipid metabolism ma o nā hana i loko o ke ake a me ka ʻōpū. Loaʻa i ka Fexaramine ka 100-fold nui affinity no FXR ma mua o nā pūhui kūlohelohe a wehewehe i nā pahuhopu genomic a me ka pūnaewele paʻa ma FXR. Ke hāʻawi waha ʻia i nā ʻiole, ua hana ka fexaramine i nā hana koho ma o nā mea loaʻa FXR i loko o ka ʻōpū. |
| CPD100577 | Lithocholic-acid | ʻO Levallorphan, ka mea i kapa ʻia ʻo levallorphan tartate (USAN), he mea modulator opioid o ka ʻohana morphinan i hoʻohana ʻia ma ke ʻano he opioid analgesic a me ka opioid antagonist/antidote. Hana ʻo ia ma ke ʻano he antagonist o ka μ-opioid receptor (MOR) a ma ke ʻano he agonist o ka κ-opioid receptor (KOR), a ma muli o ka hopena, pale i nā hopena o nā mea ikaika me ka hana intrinsic ʻoi aku ka nui e like me ka morphine i ka manawa e hana ana i ka analgesia. . Ma ke ʻano he agonist o ka KOR, hiki i ka levallorphan ke hoʻoulu i nā hopena noʻonoʻo koʻikoʻi i ka lawa kūpono e pili ana i ka hallucinations, dissociation, a me nā hopena psychotomimetic ʻē aʻe, dysphoria, hopohopo, huikau, dizziness, disorientation, derealization, manaʻo o ka ʻona, a me nā moeʻuhane ʻano ʻē aʻe. . (Kumu: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate-Isopropyl | ʻO Turofexorate isopropyl, ka mea i ʻike ʻia ʻo WAY-362450 a me XL335, he agonist ikaika loa, koho, a me ka waha o ka farnesoid X receptor (FXR) (EC(50) = 4 nM, Eff = 149%), e hoʻemi ana i ka mumū o ka ate. a me ka fibrosis i ka hoʻohālike murine o ka steatohepatitis non-alcoholic |
| CPD100574 | GW4064 | GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50为65 nM。浓度达到1 μM时，对其他核没潡他核没有他核受他。 |
| CPD1549 | Tropifexor | ʻO Tropifexor kahi moʻolelo a me ka agonist ikaika loa o FXR me kahi EC50 o 0.2 nM. |
