FLT3

CAT #	Inoa Huahana	wehewehe
CPDB0099	Quizartinib; AC-010220; AC-220	ʻO Quizartinib kahi mea pale o FMS pili tyrosine kinase 3 (FLT3; Kd = 1.6 nM) a hōʻike i ke koho kiʻekiʻe no FLT3 ke hoʻāʻo ʻia e kūʻē i kahi panel o 227 kinases hou. Hoʻopaʻa ia i ka hoʻonui ʻana o ka laina cell leukemia kanaka MV4-11, kahi i hoʻopaʻa ʻia i ka homozygous FLT3-ITD mutation, me kahi waiwai IC50 o 0.56 nM.1 Ma 1 mg / kg / lā, ua hōʻike ʻia ʻo quizartinib e hoʻolōʻihi i ke ola ʻana i ka ʻiole. kumu hoʻohālike o FLT3-ITD acute myeloid leukemia a no ka hoʻopau ʻana i nā maʻi koko i loko o ka ʻiole hilinaʻi FLT3 kŘkohu xenograft ma 10 mg/kg.