Alvocidib

Inoa Kimia:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Code InChi:

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(28-21) 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1

Ki InChi:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Hua'ōlelo:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO Alvocidib kahi pūhui synthetic N-methylpiperidinyl chlorophenyl flavone. Ma keʻano he mea hoʻopaneʻe o ka cyclin-dependent kinase, alvocidib induces cell cycle arrest ma ka pale ʻana i ka phosphorylation of cyclin-dependent kinases (CDKs) a me ka hoʻoponopono iho ʻana i ka cyclin D1 a me D3 hōʻike, ka hopena i ka hopu ʻia ʻana o ka pōʻai cell G1 a me ka apoptosis. He mea hoʻokūkū hoʻokūkū hoʻi kēia mea hana i ka hana adenosine triphosphate. E nānā no nā hoʻokolohua lapaʻau ikaika a i ʻole nā ​​hoʻokolohua lapaʻau pani ʻia me ka hoʻohana ʻana i kēia mea hana.

Kuhikuhi: CDK