i loko o vivo Pharmacokinetic Assays

ʻO kā mākou hui pharmacokinetic kūikawā i ka hoʻomohala preclinical, ka nānā ʻana i ka DMPK a me ka hoʻopaʻa inoa IND. Ua hoʻokumu mākou i kahi kahua ʻenehana screening in vitro & in vivo i kākoʻo i ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau. Hāʻawi ʻo Caerulum Pharma i ka lawelawe maʻalahi a pilikino no nā hoʻonā DMPK kūpono a me ke kumu kūʻai.

1. Haʻawina haʻawina

Nā mole liʻiliʻi, nā huahana kūlohelohe, polypeptides.

2. Loaʻa nā lawelawe

ʻO nā hōʻike PK wikiwiki ma o nā ala hoʻokele like ʻole i nā ʻano rodent a me nā ʻano mea ʻole, e like me ka ʻiole, ka ʻiole, ka ʻīlio a me ka monkey.

Māhele ʻiʻo

ʻO ka excretion a me ke kaulike nui

ʻO ka laʻana CSF a me ke komo ʻana o BBB

Hoʻomohala ʻana i ke ʻano analytical i loko o ka matrix biological

Ka helu helu o nā laʻana olaola like ʻole

ʻIkepili a me ka hāʻawi ʻana

3.DMPK pili protocol hoʻolālā a me ka hoʻokō ʻana ma muli o ke koi noiʻi kikoʻī.


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