ʻO kā mākou hui pharmacokinetic kūikawā i ka hoʻomohala preclinical, ka nānā ʻana i ka DMPK a me ka hoʻopaʻa inoa IND. Ua hoʻokumu mākou i kahi kahua ʻenehana screening in vitro & in vivo i kākoʻo i ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau. Hāʻawi ʻo Caerulum Pharma i ka lawelawe maʻalahi a pilikino no nā hoʻonā DMPK kūpono a me ke kumu kūʻai.
1. Haʻawina haʻawina
Nā mole liʻiliʻi, nā huahana kūlohelohe, polypeptides.
2. Loaʻa nā lawelawe
ʻO nā hōʻike PK wikiwiki ma o nā ala hoʻokele like ʻole i nā ʻano rodent a me nā ʻano mea ʻole, e like me ka ʻiole, ka ʻiole, ka ʻīlio a me ka monkey.
Māhele ʻiʻo
ʻO ka excretion a me ke kaulike nui
ʻO ka laʻana CSF a me ke komo ʻana o BBB
Hoʻomohala ʻana i ke ʻano analytical i loko o ka matrix biological
Ka helu helu o nā laʻana olaola like ʻole
ʻIkepili a me ka hāʻawi ʻana
3.DMPK pili protocol hoʻolālā a me ka hoʻokō ʻana ma muli o ke koi noiʻi kikoʻī.