Voruciclib

Inoa Kimia:

2-(2-Chloro-4-(trifluoromethyl)phenyl) -5,7-dihydroxy-8-((2R,3S) -2-(hydroxymethyl)-1-methylpyrrolidin-3-yl) -4H-1-benzopyran -4-hoʻokahi

SMILES Code:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Code InChi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 1 9)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

Ki InChi:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Hua'ōlelo:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO Voruciclib, ka mea i ʻike ʻia ʻo P1446A-05, he mea pale kinase kinase kikoʻī no ka cyclin-dependent kinase 4 (CDK4) me ka hana antineoplastic. Kāohi ʻia ka CDK4 inhibitor P1446A-05 i ka CDK4-mediated G1-S phase transition, ka hopu ʻana i ke kaʻa kaʻa a me ka pale ʻana i ka ulu ʻana o ka maʻi kanesa. Loaʻa ka serine/threonine kinase CDK4 i loko o kahi paʻakikī me D-type G1 cyclins a ʻo ia ka kinase mua i hoʻāla ʻia ma luna o ka hoʻoulu ʻana i ka mitogenic, e hoʻokuʻu ana i nā cell mai kahi pae kuʻi i ka pae kaʻa kaʻa ulu G1 / S; Ua hōʻike ʻia nā paʻakikī CDK-cyclin i ka phosphorylate i ka retinoblastoma (Rb) transcription factor i ka G1 mua, ka hoʻoneʻe ʻana i ka histone deacetylase (HDAC) a me ka pale ʻana i ka repression transcriptional.

Pahuhopu: CDK4