THZ2
Huahana Huahana
Huahana Huahana
Nui Puke | Loaʻa | Kumukuai (USD) |
100mg | Loaʻa | 500 |
500mg | Loaʻa | 800 |
1g | Loaʻa | 1200 |
Nui hou aku | E kiʻi i nā huaʻōlelo | E kiʻi i nā huaʻōlelo |
Inoa Kimia:
N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)akā-2- enoyl]amino]benzamide
SMILES Code:
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN (C)C)=O)=C5
Code InChi:
InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+
Ki InChi:
FONRCZUZCHXWBD-VGOFMYFVSA-N
Hua'ōlelo:
THZ-2, THZ 2, THZ2, 1604810-84-5
Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO
Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).
wehewehe:
ʻO THZ2, kahi analog o THZ1, me ka hiki ke mālama i ka Triple-negative breast cancer (TNBC), he mea hoʻopaneʻe CDK7 ikaika a koho i lanakila i ka instability o THZ1 in vivo. IC50: CDK7= 13.9 nM; Nā pūnaewele TNBC= 10 nM
Kuhikuhi: CDK