Riviciclib

Inoa Kimia:

2-(2-chlorophenyl) -5,7-dihydroxy-8-((2R,3S) -2-(hydroxymethyl)-1-methylpyrrolidin-3-yl) -4H-chromen-4-one hydrochloride

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Code InChi:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

Ki InChi:

OOVTUOCTLAERQD-OJMBIDBESA-N

Hua'ōlelo:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO Riviciclib, i kapa ʻia ʻo P276-00, he flavone a me ka cyclin dependent kinase (CDK) inhibitor me ka hana antineoplastic. P276-00 koho a hoʻopaʻa i ka Cdk4/cyclin D1, Cdk1/cyclin B a me Cdk9/cyclin T1, serine/threonine kinases e pāʻani ana i nā kuleana koʻikoʻi i ka hoʻoponopono ʻana i ka pōʻai cell a me ka hoʻonui ʻana o nā kelepona. ʻO ka hoʻopaʻa ʻana i kēia mau kinases e alakaʻi i ka hopu ʻana i ka cell cycle i ka wā o ka hoʻololi ʻana o G1/S, a laila e alakaʻi ana i kahi induction o apoptosis, a me ka pale ʻana i ka hoʻonui ʻana o ka cell tumor.

Kuhikuhi: CDK