SEL120-34A

Inoa Kimia:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride

SMILES Code:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Code InChi:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

Ki InChi:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Hua'ōlelo:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO SEL120-34A kahi mea hoʻopale CDK8 ikaika a koho i loko o nā pūnaewele AML me nā kiʻekiʻe o ka serine phosphorylation o STAT1 a me STAT5 transactivation domain. Kāohi ʻo EL120-34A i ka phosphorylation o STAT1 S727 a me STAT5 S726 i loko o nā pūnana maʻi maʻi in vitro. I ka manawa like, ua ʻike ʻia ka hoʻoponopono ʻana o STATs- a me NUP98-HOXA9- hilinaʻi transcription ma ke ʻano he hana mana o ka hana ma vivo.

Pahuhopu: CDK8