| CAT # | Inoa Huahana | wehewehe |
| CPD100464 | ʻO Erdafitinib | ʻO Erdafitinib, ka mea i ʻike ʻia ʻo JNJ-42756493, he mea ikaika a koho ʻia i ka waha, pan fibroblast growth factor receptor (FGFR) inhibitor me ka hana antineoplastic. Ma luna o ka hoʻoponopono waha, JNJ-42756493 hoʻopaʻa a hoʻopaʻa i ka FGFR, hiki ke hopena i ka pale ʻana i nā ala transduction hōʻailona pili i ka FGFR a no laila ke kāohi ʻana i ka hoʻonui ʻana o ka cell tumo a me ka make cell tumor i FGFR-overexpressing tumor cell. ʻO FGFR, i hoʻoponopono ʻia i loko o nā ʻano cell tumor he nui, he receptor tyrosine kinase e pono ai i ka hoʻonui ʻana o nā cell tumor, ka ʻokoʻa a me ke ola. |
| CPD3618 | TAS-120 | ʻO ka TAS-120 kahi mea hoʻopaneʻe waha o ka fibroblast growth factor receptor (FGFR) me ka hana antineoplastic. FGFR inhibitor TAS-120 selectively a irreversibly nakinaki a inhibits FGFR, i hiki ke hopena i ka inhibition o ka FGFR-mediated hōʻailona transduction alahele a me tumor cell proliferation, a me ka hoʻonui i ka make cell i FGFR-overexpressing puʻupuʻu maʻi. ʻO FGFR kahi mea hoʻokae tyrosine kinase e pono ai i ka hoʻonui ʻana o ka cell tumor, ka ʻokoʻa a me ke ola ʻana a ua hoʻoponopono ʻia kona ʻōlelo i nā ʻano cell tumor he nui. |
| CPDB1093 | Derazantinib; ARQ-087 | ʻO Derazantinib, ka mea i kapa ʻia ʻo ARQ-087, he mea hoʻopaneʻe waha bioavailable o ka fibroblast growth factor receptor (FGFR) me ka hana antineoplastic. |
| CPDB0942 | BLU-554 | ʻO BLU-554 kahi mea hoʻopaneʻe fibroblast growth factor receptor 4 (FGFR4) hiki ke mālama i ka maʻi hepatocellular carcinoma a me cholangiocarcinoma. |
| CPD0999 | H3B-6527 | ʻO H3B-6527 (H3 Biomedicine) he mea hoʻopaneʻe FGFR4 i koho nui ʻia me ka hana antitumour ikaika ma FGF19 i hoʻonui ʻia i nā laina kelepona a me nā ʻiole. |
| CPD0997 | FGF401 | ʻO FGF-401 ka mea hoʻopaneʻe o FGFR4 i unuhi ʻia mai ka patent WO2015059668A1, ka laʻana hui 83; he IC50 o 1.9 nM. |
| CPDB0053 | AZD4547 | ʻO AZD 4547 he mea hoʻopaneʻe koho o ka fibroblast growth factor receptor (FGFR) tyrosine kinase me nā koina IC50 o 0.2, 2.5, a me 1.8 nM no FGFR1, 2, a me 3. |
| CPD3610 | BLU-9931 | ʻO BLU9931 he mea hoʻopaneʻe FGFR4 ikaika, koho, a hiki ʻole ke hoʻololi ʻia me IC50 o 3 nM, ma kahi o 297-, 184-, a me 50-fold selectivity ma luna o FGFR1/2/3. |
