BS-181

Inoa Kimia:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo [1,5-a] pyrimidine-5,7-diamine hydrochloride

SMILES Code:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Code InChi:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19)28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3,(H,24,27);1H

Ki InChi:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Hua'ōlelo:

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO BS-181 kahi mea hoʻopaneʻe CDK koho loa no CDK7 me kahi IC(50) o 21 nmol/L. ʻO ka hoʻāʻo ʻana i nā CDK ʻē aʻe a me nā kinase 69 ʻē aʻe i hōʻike ʻia ʻo BS-181 wale nō ke kāohi i ka CDK2 ma nā haʻahaʻa haʻahaʻa haʻahaʻa ma mua o 1 micromol/L, me ka CDK2 i hoʻopaʻa ʻia he 35-fold ka liʻiliʻi (IC(50) 880 nmol/L) ma mua o CDK7. I loko o nā pūnaewele MCF-7, ua kāohi ʻo BS-181 i ka phosphorylation o nā substrates CDK7, hoʻoikaika i ka hopu ʻana o ka cell cycle a me ka apoptosis e pale ai i ka ulu ʻana o nā laina maʻi kanesa, a hōʻike i nā hopena antitumor i vivo.

Pahuhopu: CDK7