CP-456773 sodium

Inoa Kimia:

sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide

SMILES Code:

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

Code InChi:

InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1

Ki InChi:

LFQQNXFKPNZRFT-UHFFFAOYSA-M

huaʻōlelo:

MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 paʻakai sodium, Cytokine hoʻokuʻu lāʻau pale 3, 256373-96-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO CP-456773, ka mea i kapa ʻia ʻo MCC950 a me CRID3, he mea hoʻokuʻu cytokine hoʻokuʻu ikaika a koho a NLRP3 inflammasome inhibitor no ka mālama ʻana i nā maʻi inflammatory. Kāohi ʻo CP-456773 i ka interleukin 1β (IL-1β) huna a me ka hana caspase 1. Ua ālai ʻia ʻo MCC950 i ka canonical a me ka noncanonical NLRP3 activation ma nā nanomolar concentrations. Kāohi pono ʻia ʻo MCC950 i ka hoʻāla ʻana o NLRP3 akā ʻaʻole nā ​​AIM2, NLRC4 a i ʻole NLRP1 inflammasomes. Ua hōʻemi ʻo MCC950 i ka hana interleukin-1β (IL-1β) i loko o ka vivo a ua hoʻemi i ka paʻakikī o ka hoʻokolohua autoimmune encephalomyelitis (EAE), kahi ʻano maʻi o ka sclerosis lehulehu. ʻO ka MCC950 he lāʻau lapaʻau kūpono no nā maʻi pili i ka NLRP3, me nā maʻi autoinflammatory a me nā maʻi autoimmune, a me kahi mea hana no ka noiʻi hou ʻana i ka inflammasome NLRP3 i ke olakino kanaka a me nā maʻi.

Kuhikuhi: NLRP3