LDC000067

Inoa Kimia:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

SMILES Code:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Code InChi:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13( 9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

Ki InChi:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Hua'ōlelo:

LDC000067; LDC-000067; LDC 000067

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO LDC000067 kahi mea hoʻopale CDK9 ikaika a koho. LDC000067 inhibited in vitro transcription in a ATP-competitive and dose-dependent manner. Hōʻike ʻia ka hōʻike ʻana o Gene expression profile o nā cell i mālama ʻia me LDC000067 i kahi hōʻemi koho o nā mRNA pōkole, me nā mea hoʻoponopono koʻikoʻi o ka hoʻonui a me ka apoptosis. ʻO ka loiloi o ka de novo RNA synthesis i manaʻo i kahi kūlana maikaʻi ākea o CDK9. Ma ka pae molecular a me ka cellular level, LDC000067 reproduced effects hiʻona o ka CDK9 inhibition e like me ka hoʻonui ʻana i ka pausing o RNA polymerase II ma nā genes a, ʻo ka mea nui loa, ka hoʻokomo ʻana o ka apoptosis i loko o nā pūnana maʻi maʻi. Kāohi ʻo LDC000067 i ka P-TEFb i hilinaʻi ʻia i ka transcription in vitro. Induces apoptosis in vitro a in vivo i hui pū me BI 894999.

Pahuhopu: CDK9