THZ531
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 500 |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (i-dimethylamino) kodwa-2-enamide
Ikhodi ye-SMILES:
"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "
Ikhodi ye-InChi:
I-InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36- 30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5 ,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1
I-InChi Key:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Igama elingukhiye:
THZ-531, THZ 531, THZ531, 1702809-17-3
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
I-THZ531 iyi-covalent CDK12 kanye ne-CDK13 covalent inhibitor. I-Cyclin-dependent kinases 12 kanye ne-13 (CDK12 ne-CDK13) idlala indima ebalulekile ekulawuleni ukulotshwa kofuzo. I-THZ531 iqondise ngendlela engenakuhlehliswa i-cysteine etholakala ngaphandle kwesizinda se-kinase. I-THZ531 idala ukulahleka kwesisho sofuzo ngokulahleka okuhambisanayo kwe-elongating ne-hyperphosphorylated RNA polymerase II. I-THZ531 inciphisa kakhulu ukubonakaliswa kwezakhi zofuzo zokulimala kwe-DNA kanye nezakhi zofuzo zesici sokuloba esihlobene nesithuthukisi esikhulu kakhulu. I-THZ531 idale ukufa kwamaseli e-apoptotic. Ama-molecule amancane akwazi ukukhomba ngokuqondile i-CDK12 ne-CDK13 angasiza ukuhlonza izinhlobo ezincane zomdlavuza ezincike ikakhulukazi emisebenzini yazo ye-kinase.
Ithagethi: CDK
