I-Voruciclib

Igama Lekhemikhali:

2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-okukodwa

Ikhodi ye-SMILES:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Ikhodi ye-InChi:

I-InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

I-InChi Key:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Igama elingukhiye:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-Voruciclib, eyaziwa nangokuthi i-P1446A-05, iyi-protein kinase inhibitor eqondene ngqo ne-cyclin-dependent kinase 4 (CDK4) enekhono lomsebenzi we-antineoplastic. I-CDK4 inhibitor P1446A-05 ivimbela ngokuqondile ukuguqulwa kwesigaba se-CDK4-mediated G1-S, ukubopha ukujikeleza kwamaseli kanye nokuvimbela ukukhula kwamangqamuzana omdlavuza. I-serine/threonine kinase CDK4 itholakala kunkimbinkimbi enamabhayisikili ohlobo lwe-D-G1 futhi iyi-kinase yokuqala ukwenziwa isebenze phezu kokukhuthazwa kwe-mitogenic, ikhipha amaseli ukusuka esigabeni esithule ukuya esigabeni sokukhula samabhayisikili se-G1/S; Ama-CDK-cyclin complexes aboniswe njenge-phosphorylate the retinoblastoma (Rb) transcription factor ekuqaleni kwe-G1, asusa i-histone deacetylase (HDAC) futhi avimbe ukucindezelwa kokubhaliwe.

Ithagethi: CDK4