I-SEL120-34A

Igama Lekhemikhali:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride

Ikhodi ye-SMILES:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Ikhodi ye-InChi:

I-InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

I-InChi Key:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Igama elingukhiye:

I-SEL120-34A; I-SEL 120-34A; I-SEL-120-34A; I-SEL12034A; I-SEL 12034A; I-SEL-12034A

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-SEL120-34A iyi-CDK8 inhibitor enamandla futhi ekhethayo esebenza kumaseli e-AML anamazinga aphezulu e-serine phosphorylation ye-STAT1 kanye ne-STAT5 transactivation domain. I-EL120-34A ivimbela i-phosphorylation ye-STAT1 S727 ne-STAT5 S726 kumaseli omdlavuza ku-vitro. Ngokuqhubekayo, ukulawulwa kwe-STATs- kanye nokuloba okuncike ku-NUP98-HOXA9- kuye kwaqashelwa njengendlela ehamba phambili yokusebenza ku-vivo.

Ithagethi: CDK8