Ithimba lethu le-pharmacokinetic lisebenza ngokukhethekile ekuthuthukisweni kwangaphambi komtholampilo, ukuhlolwa kwe-DMPK nokubhaliswa kwe-IND. Sakhe inkundla edidiyelwe ye-in vitro & in vivo yokuhlola ubuchwepheshe ukuze sisekele ukutholwa nokuthuthukiswa kwezidakamizwa. I-Caerulum Pharma inikeza isevisi evumelana nezimo neyomuntu siqu ukuze uthole izixazululo ze-DMPK ezisebenza kahle nezingabizi.
1.Izingxenye zokufunda
Ama-molecule amancane, imikhiqizo yemvelo, ama-polypeptides.
2.Amasevisi atholakalayo
Ukuhlolwa okusheshayo kwe-PK kusetshenziswa imizila ehlukahlukene yokuphatha ezinhlotsheni zamagundane nezingewona ama-rodent, njengegundane, igundane, inja nenkawu.
Ukusatshalaliswa kwezicubu
I-Excretion kanye nebhalansi enkulu
Isampula ye-CSF kanye nokungena kwe-BBB
Ukuthuthukiswa kwendlela yokuhlaziya ku-matrix yebhayoloji
Ukuhlaziywa komthamo kwamasampuli ahlukahlukene ebhayoloji
Ukucubungula nokulethwa kwedatha
3.DMPK idizayini yephrothokholi ehlobene nokusebenza ngokususelwe esidingweni esicacisiwe socwaningo.