I-CB-839

Igama Lekhemikhali:

2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol -2-yl)i-acetamide

Ikhodi ye-SMILES:

O=C(NC1=CC=C(CCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC =C4

Ikhodi ye-InChi:

I-InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21)7-1-2-10-24- 35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7, 10,15-16H2,(H,31,34,37)(H,32,36,38)

I-InChi Key:

I-PRAAPINBUWJLGA-UHFFFAOYSA-N

Igama elingukhiye:

CB-839, CB839, CB 839, 1439399-58-2

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

"I-CB-839 i-oral bioavailable inhibitor ye-glutaminase, enomsebenzi ongase ube ne-antineoplastic. Lapho iphathwa ngomlomo, i-CB-839 ivimbela ngokukhethayo futhi ngokungenakuphikiswa i-glutaminase, i-enzyme ye-mitochondrial ebalulekile ekuguqulweni kwe-amino acid glutamine Ngokuvimba i-glutamine. ukusetshenziswa, ukwanda kwamaseli akhula ngokushesha Izimila ezincike ku-Glutamine zithembele ekuguqulweni kwe-glutamine yangaphandle ibe yi-glutamate kanye ne-glutamate metabolites ukuze inikeze amandla futhi ikhiqize amabhlokhi wokwakha ama-macromolecules, adingekayo ekukhuleni kwamaselula kanye nokuphila ".

Ithagethi: Glutaminase