I-MC180295

Igama Lekhemikhali:

I-Rel-(4-amino-2-(((2S)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone

Ikhodi ye-SMILES:

O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

Ikhodi ye-InChi:

I-InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16 )19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10? ,12-/m0/s1

I-InChi Key:

JRNXAQINDCOHGS-CBINBANVSA-N

Igama elingukhiye:

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-MC180295 iyi-CDK9 inhibitor ekhetha kakhulu (IC50 = 5 nM). (I-MC180295 inomsebenzi obanzi wokulwa nomdlavuza ku-vitro futhi iyasebenza kumamodeli womdlavuza we-vivo. Ukwengeza, i-CDK9 inhibition izwela i-immune checkpoint inhibitor α-PD-1 ku-vivo, ikwenze kube okuhlosiwe okuhle kakhulu kwe-epigenetic therapy yomdlavuza.

Ithagethi: CDK9