Ithimba lethu le-pharmacokinetic ligxile ekuthuthukisweni kwangaphambi komtholampilo, ukuhlolwa kwe-DMPK nokubhaliswa kwe-IND. Sakhe inkundla edidiyelwe ye-in vitro & in vivo yokuhlola ubuchwepheshe ukuze sisekele ukutholwa nokuthuthukiswa kwezidakamizwa. I-Caerulum Pharma inikeza isevisi evumelana nezimo neyomuntu siqu ukuze uthole izixazululo ze-DMPK ezisebenza kahle nezingabizi ukuze uqhubekisele phambili ucwaningo lwakho.
1.Izingxenye zokufunda
Ama-molecule amancane, imikhiqizo yemvelo, ama-polypeptides.
2.Amasevisi atholakalayo
Ukuhlolwa kokubopha amaprotheni e-Plasma/tissue
Isilinganiso se-plasma negazi
Ukuqina kwe-metabolism ye-microsomal yesibindi
Ukuzinza emotweni nakuplasma
Ukuhlonza i-Metabolite
I-CYP yokusabela phenotyping
Ukuvinjelwa kwe-CYP
3.Ekwakhiweni
I-Hepatocyte Induction
I-Caco-2 Permeability
Ukusabela kwe-UGT phenotyping