I-Rivicclib

I-Rivicclib
  • Igama:I-Rivicclib
  • Inombolo yekhathalogi:I-CPD100907
  • Inombolo ye-CAS:920113-03-7 (HCl) 920113-02-6 (isisekelo samahhala)
  • Isisindo se-Molecular:401.103
  • I-Chemical Formula:I-C21H21Cl2NO5
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)

    Igama Lekhemikhali:

    2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

    Ikhodi ye-SMILES:

    O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

    Ikhodi ye-InChi:

    I-InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

    I-InChi Key:

    I-OOVTUOCTLAERQD-OJMBIDBESA-N

    Igama elingukhiye:

    P276-00; P-276-00; P 276-00; I-P-27600; P 27600; P 27600; I-Riviciclib, i-Riviciclib HCl

    Ukunyibilika: 

    Isitoreji: 

    Incazelo:

    I-Riviciclib, eyaziwa nangokuthi i-P276-00, iyi-flavone ne-cyclin encike kinase (CDK) inhibitor enomsebenzi ongaba khona we-antineoplastic. I-P276-00 ibopha ngokukhetha futhi ivimbele i-Cdk4/cyclin D1, i-Cdk1/cyclin B ne-Cdk9/cyclin T1, i-serine/threonine kinases edlala izindima ezibalulekile ekulawuleni umjikelezo weseli nokwanda kwamaselula. Ukuvinjelwa kwalawa ma-kinase kuholela ekuboshweni komjikelezo weseli ngesikhathi soguquko lwe-G1/S, ngaleyo ndlela kuholele ekungenweni kwe-apoptosis, kanye nokuvinjwa kokwanda kwamaseli wesimila.

    Ithagethi: CDK


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