I-Alvocidib
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
Igama Lekhemikhali:
2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one
Ikhodi ye-SMILES:
O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13
Ikhodi ye-InChi:
I-InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- ,17+/m1/s1
I-InChi Key:
I-BIIVYFLTOXDAOV-PXAZEXFGSA-N
Igama elingukhiye:
L 86-8275; L-868275; L 868275; L868275; HMR 1274; I-HMR-1274; I-HMR1274; I-Flavoperidol; I-Alvocidib
Ukunyibilika:
Isitoreji:
Incazelo:
I-Alvocidib iyinhlanganisela ye-N-methylpiperidinyl chlorophenyl flavone yokwenziwa. Njenge-inhibitor ye-cyclin-dependent kinase, i-alvocidib inxusa ukuboshwa komjikelezo weseli ngokuvimbela i-phosphorylation ye-cyclin-dependent kinases (CDKs) kanye nenkulumo elawula phansi ye-cyclin D1 kanye ne-D3, okuholela ekuboshweni komjikelezo weseli ye-G1 kanye ne-apoptosis. Le ejenti iphinde ibe inhibitor yokuncintisana yomsebenzi we-adenosine triphosphate. Hlola izivivinyo zomtholampilo ezisebenzayo noma izivivinyo zomtholampilo ezivaliwe usebenzisa lesi sisebenzeli.
Ithagethi: CDK