I-Alvocidib

I-Alvocidib
  • Igama:I-Alvocidib
  • Inombolo yekhathalogi:I-CPD100905
  • Inombolo ye-CAS:131740-09-5 (HCl) 146426-40-6 (isisekelo samahhala)
  • Isisindo se-Molecular:401.84
  • I-Chemical Formula:I-C21H20ClNO5
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)

    Igama Lekhemikhali:

    2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

    Ikhodi ye-SMILES:

    O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

    Ikhodi ye-InChi:

    I-InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- ,17+/m1/s1

    I-InChi Key:

    I-BIIVYFLTOXDAOV-PXAZEXFGSA-N

    Igama elingukhiye:

    L 86-8275; L-868275; L 868275; L868275; HMR 1274; I-HMR-1274; I-HMR1274; I-Flavoperidol; I-Alvocidib

    Ukunyibilika: 

    Isitoreji: 

    Incazelo:

    I-Alvocidib iyinhlanganisela ye-N-methylpiperidinyl chlorophenyl flavone yokwenziwa. Njenge-inhibitor ye-cyclin-dependent kinase, i-alvocidib inxusa ukuboshwa komjikelezo weseli ngokuvimbela i-phosphorylation ye-cyclin-dependent kinases (CDKs) kanye nenkulumo elawula phansi ye-cyclin D1 kanye ne-D3, okuholela ekuboshweni komjikelezo weseli ye-G1 kanye ne-apoptosis. Le ejenti iphinde ibe inhibitor yokuncintisana yomsebenzi we-adenosine triphosphate. Hlola izivivinyo zomtholampilo ezisebenzayo noma izivivinyo zomtholampilo ezivaliwe usebenzisa lesi sisebenzeli.

    Ithagethi: CDK


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